2026-06-14T03:39:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/90932024-09-27T22:24:30Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Lorente, Elena
author
Barriga, Alejandro
author
Barnea, Eilon
author
Mir-Gerrero, Carmen
author
Gebe, John A
author
Admon, Arie
author
Lopez, Daniel
funder
Ministerio de Economía y Competitividad (España)
2020-02-14T11:46:28Z
2020-02-14T11:46:28Z
2016
Mol Cell Proteomics. 2016 Jun;15(6):2141-51.
10.1074/mcp.M115.057356
1535-9484
1535-9476
Molecular & cellular proteomics : MCP
27090790
http://hdl.handle.net/20.500.12105/9093
Proper antiviral humoral and cellular immune responses require previous recognition of viral antigenic peptides that are bound to HLA class II molecules, which are exposed on the surface of antigen-presenting cells. The helper immune response is critical for the control and the clearance of human respiratory syncytial virus (HRSV) infection, a virus with severe health risk in infected pediatric, immunocompromised, and elderly populations. In this study, using a mass spectrometry analysis of complex HLA class II-bound peptide pools that were isolated from large amounts of HRSV-infected cells, 19 naturally processed HLA-DR ligands, most of them included in a complex nested set of peptides, were identified. Both the immunoprevalence and the immunodominance of the HLA class II response to HRSV were focused on one nonstructural (NS1) and two structural (matrix and mainly fusion) proteins of the infective virus. These findings have clear implications for analysis of the helper immune response as well as for antiviral vaccine design.
eng
Structural and Nonstructural Viral Proteins Are Targets of T-Helper Immune Response against Human Respiratory Syncytial Virus
journal article
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URL
https://repisalud.isciii.es/bitstreams/6fb65dd4-0353-483d-8573-435230891533/download
File
MD5
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application/pdf
StructuralAndNonstructuralViral_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/94aae7c9-4674-4268-a2aa-e186a4190018/download
File
MD5
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text/plain
StructuralAndNonstructuralViral_2016.pdf.txt