2026-04-27T01:59:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/90792024-09-27T21:52:16Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez, Luis Miguel
author
Castro, Emma
author
Lobo, Cheryl A
author
Richart, Alberto
author
Ramiro-Jimenez, Raquel
author
Gonzalez-Camacho, Fernando
author
Luque, Daniel
author
Velasco, Aurelio C
author
Montero-Clemente, Estrella
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
2020-02-12T12:20:51Z
2020-02-12T12:20:51Z
2015-04
Int J Infect Dis. 2015 Apr;33:202-4.
1201-9712
http://hdl.handle.net/20.500.12105/9079
25686807
10.1016/j.ijid.2015.02.005
1878-3511
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Human babesiosis is a zoonosis primarily transmitted through Ixodes ticks and alternatively by routes such as blood transfusions from asymptomatic donors. We report the first case of human babesiosis caused by Babesia divergens in a patient with HIV. This study also focuses on elucidating the possible transmission route of infection in this patient, who received numerous blood transfusions but showed patent symptoms only after splenectomy. A battery of detection tools along with a novel Western-Blot Assay and Enzyme Linked Immunosorbent Assay using the major surface protein of B. divergens (Bd37) as a target were used to evaluate the presence of B. divergens or antibodies against the parasite in samples from the patient and the blood donors involved in this case. A retrospective study of the humoral status against the parasite revealed B. divergens IgG antibodies in one of the implicated donors, but also showed that the patient had been already exposed to the parasite before any transfusion. Thus, this analysis of natural and transfusion transmission routes suggests a pre-existing subclinical babesiosis in the patient.
eng
Babesia divergens
HIV
Babesiosis
Blood transfusion
Patient
Transmission route
First report of Babesia divergens infection in an HIV patient
journal article
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FirstReportOfBabesia_2015.pdf
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FirstReportOfBabesia_2015.pdf.txt