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oai:repisalud.isciii.es:20.500.12105/90012025-04-25T08:10:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Perez-Sautu, Unai author Pozo Sanchez, Francisco author Cuesta de la Plaza, Isabel author Monzon-Fernandez, Sara author Calderon-Reñon, Ana Maria author Gonzalez, M author Molinero, Mar author López-Miragaya, Isabel author Rey, Sonia author Cañizares, A author Rodriguez, G author Gonzalez-Velasco, C author Lackenby, A author Casas Flecha, Inmaculada author 2014-07-10 The Y155H amino acid substitution in the neuraminidase gene (NA) has previously been associated with highly reduced inhibition by neuraminidase inhibitors in the seasonal H1N1 influenza A virus which circulated in humans before the 2009 pandemic. During the 2012/13 epidemic season in Spain, two A(H1N1) pdm09 viruses bearing the specific Y155H substitution in the NA were detected and isolated from two patients diagnosed with severe respiratory syndrome and pneumonia requiring admission to the intensive care unit. Contrary to what was observed in the seasonal A(H1N1) viruses, neither of the Y155H A(H1N1) pdm09 viruses described here showed a phenotype of reduced inhibition by NAIs as determined by the neuraminidase enzyme inhibition assay (MUNANA). High-throughput sequencing of the NA of both Y155H viruses showed that they were composed to >99% of H155 variants. We believe that this report can contribute to a better understanding of the biological significance of amino acid substitutions in the neuraminidase protein with regard to susceptibility of influenza viruses to neuraminidase inhibitors. This is of critical importance for optimal management of influenza disease patients. Euro Surveill. 2014 Jul 10;19(27):14-20. 10.2807/1560-7917.ES2014.19.27.20849 1560-7917 Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 25033052 http://hdl.handle.net/20.500.12105/9001 Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced susceptibility to neuraminidase inhibitors