2026-06-14T03:32:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89782024-09-27T20:32:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Ibarra-Meneses, Ana Victoria
author
Carrillo, Eugenia
author
Nieto Martinez, Francisco Javier
author
Sanchez Herrero, Carmen
author
Ortega, Sheila
author
Estirado, Alicia
author
Latasa Zamalloa, Pello
author
Sanz, Juan Carlos
author
Garcia Comas, Luis
author
Ordobás, María
author
Moreno, Javier
funder
Instituto de Salud Carlos III
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-01-29T11:49:39Z
2020-01-29T11:49:39Z
2019-05
Euro Surveill. 2019 May;24(22).
10.2807/1560-7917.ES.2019.24.22.1800379
1560-7917
1560-7917
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
31164191
http://hdl.handle.net/20.500.12105/8978
BackgroundA large outbreak of leishmaniasis with 758 cutaneous and visceral leishmaniasis cases occurred in 2009 in Fuenlabrada, in the south-west of the Madrid region of Spain.AimWe aimed to determine the prevalence of asymptomatic Leishmania infection after this outbreak, and its associated risk factors.MethodsA cross-sectional study of 804 healthy individuals living in Fuenlabrada who had no history of leishmaniasis, was conducted between January and July 2015. Asymptomatic infections were sought by either a combination of PCR, immunofluorescent antibody titre, and direct agglutination tests, or by whole blood stimulation assay (WBA) with interleukin-2 (IL-2) quantification.ResultsUsing the first approach, prevalence of asymptomatic individuals was 1.1% (9/804), while the second returned a value of 20.7% (143/804). Older age, being male, proximity to the park where the focus of infection was identified, and living in a detached house, were all strongly associated with the prevalence of asymptomatic infection.ConclusionsThe true number of infected individuals may be underestimated if only serological methods are used. The combination of WBA with IL-2 quantification may allow to better determine the prevalence of asymptomatic Leishmania infection, which would be useful in establishing control measures and in quantifying their impact. In our study, the use of WBA with IL-2 quantification also helped establish the risk factors that influence exposure to and infection by Leishmania.
eng
Leishmania
Spain
Asymptomatic infection
Epidemiological survey
Epidemiology
Interleukin-2
Leishmaniasis
Outbreaks
Risk factors
Surveillance
Whole blood stimulated assay
Prevalence of asymptomatic Leishmania infection and associated risk factors, after an outbreak in the south-western Madrid region, Spain, 2015
journal article
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PrevalenceOfAsymptomaticLeishmania_2019.pdf.txt