2026-06-14T03:29:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/89772024-09-27T21:30:28Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Jarlier, Vincent author Diaz Högberg, Liselotte author Heuer, Ole E author Campos, Jose author Eckmanns, Tim author Giske, Christian G author Grundmann, Hajo author Johnson, Alan P author Kahlmeter, Gunnar author Monen, Jos author Pantosti, Annalisa author Rossolini, Gian Maria author van de Sande-Bruinsma, Nienke author Vatopoulos, Alkiviadis author Żabicka, Dorota author Žemličková, Helena author Monnet, Dominique L author Simonsen, Gunnar Skov author 2019 BackgroundAntibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.AimOur objective was to compare the country-specific species distribution of the four Gram-negative species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species and the proportions of selected acquired resistance traits within these species.MethodWe used data reported for 2016 to the European Antimicrobial Resistance Surveillance Network (EARS-Net) by 30 countries in the European Union and European Economic Area.ResultsThe country-specific species distribution varied considerably. While E. coli accounted for 31.9% to 81.0% (median: 69.0%) of all reported isolates, the two most common intrinsically resistant species P. aeruginosa and Acinetobacter spp. combined (PSEACI) accounted for 5.5% to 39.2% of isolates (median: 10.1%). Similarly, large national differences were noted for the percentages of acquired non-susceptibility to third-generation cephalosporins, carbapenems and fluoroquinolones. There was a strong positive rank correlation between the country-specific percentages of PSEACI and the percentages of non-susceptibility to the above antibiotics in all four species (rho > 0.75 for 10 of the 11 pairs of variables tested).ConclusionCountries with the highest proportion of P. aeruginosa and Acinetobacter spp. were also those where the rates of acquired non-susceptibility in all four studied species were highest. The differences are probably related to national differences in antibiotic consumption and infection prevention and control routines. Euro Surveill. 2019 Aug;24(33). 10.2807/1560-7917.ES.2019.24.33.1800538 1560-7917 1560-7917 Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 31431208 http://hdl.handle.net/20.500.12105/8977 Gram-negative bacilli Antibiotic resistance Antimicrobial resistance Bacterial infections Bloodstream infection Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016