2026-06-14T03:32:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89702025-06-09T13:56:05Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Ramirez de Arellano, Eva
author
Sanchez-Lockhart, Mariano
author
Perteguer-Prieto, Maria Jesus
author
Bartlett, Maggie
author
Ortiz Rivera, Marta
author
Campioli, Pamela
author
Hernandez-Gonzalez, Ana
author
Gonzalez, Jeanette
author
Garcia, Karla
author
Ramos, Manuel
author
Jiménez-Clavero, Miguel Ángel
author
Tenorio, Antonio
author
Sánchez-Seco, María Paz
author
González, Félix
author
Echevarria, Juan Emilio
author
Palacios, Gustavo
author
Negredo, Anabel
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
National Science Foundation (Estados Unidos)
2020-01-29T11:46:47Z
2020-01-29T11:46:47Z
2019
Viruses. 2019 Apr 19;11(4). pii: E360.
10.3390/v11040360
1999-4915
1999-4915
Viruses
31010201
http://hdl.handle.net/20.500.12105/8970
Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats (n = 60), common serotine bats (n = 10) as controls, and humans (n = 22) using an immunoblot assay. We found antibodies against LLOV GP2 in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. To confirm this seroreactivity, 52 serums were individually tested using Domain Programmable Arrays (DPA), a phage display based-system serology technique for profiling filovirus epitopes. A serological signature against different LLOV proteins was obtained in 19/52 samples tested (36.5%). The immunodominant response was in the majority specific to LLOV-unique epitopes, confirming that the serological response detected was to LLOV. To our knowledge, this is the first serological evidence of LLOV exposure in live captured Schreiber's Bent-winged bats, dissociating LLOV circulation as the cause of the previously reported die-offs.
eng
Bats
Human
Lloviu virus
Prevalence
Serology
First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain
research article
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URL
https://repisalud.isciii.es/bitstreams/2221ee34-88ab-49a9-8508-ebc8a48e09aa/download
File
MD5
29379c908fdace092de18472b426589a
3959760
application/pdf
FirstEvidenceOfAntibodies_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/790e145b-dbbd-4ea2-833a-100e5836b413/download
File
MD5
801c0b980781fbd61b8af29fca96bdca
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text/plain
FirstEvidenceOfAntibodies_2019.pdf.txt