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oai:repisalud.isciii.es:20.500.12105/89702025-06-09T13:56:05Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Ramirez de Arellano, Eva author Sanchez-Lockhart, Mariano author Perteguer-Prieto, Maria Jesus author Bartlett, Maggie author Ortiz Rivera, Marta author Campioli, Pamela author Hernandez-Gonzalez, Ana author Gonzalez, Jeanette author Garcia, Karla author Ramos, Manuel author Jiménez-Clavero, Miguel Ángel author Tenorio, Antonio author Sánchez-Seco, María Paz author González, Félix author Echevarria, Juan Emilio author Palacios, Gustavo author Negredo, Anabel author 2019 Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats (n = 60), common serotine bats (n = 10) as controls, and humans (n = 22) using an immunoblot assay. We found antibodies against LLOV GP2 in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. To confirm this seroreactivity, 52 serums were individually tested using Domain Programmable Arrays (DPA), a phage display based-system serology technique for profiling filovirus epitopes. A serological signature against different LLOV proteins was obtained in 19/52 samples tested (36.5%). The immunodominant response was in the majority specific to LLOV-unique epitopes, confirming that the serological response detected was to LLOV. To our knowledge, this is the first serological evidence of LLOV exposure in live captured Schreiber's Bent-winged bats, dissociating LLOV circulation as the cause of the previously reported die-offs. Viruses. 2019 Apr 19;11(4). pii: E360. 10.3390/v11040360 1999-4915 1999-4915 Viruses 31010201 http://hdl.handle.net/20.500.12105/8970 Bats Human Lloviu virus Prevalence Serology First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain