2026-04-29T16:56:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89672024-09-27T19:59:28Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rivero-Menendez, Olga
author
Alastruey-Izquierdo, Ana
author
Mellado, Emilia
author
Cuenca-Estrella, Manuel
funder
Instituto de Salud Carlos III
2020-01-29T11:45:42Z
2020-01-29T11:45:42Z
2016-07-04
J Fungi (Basel). 2016 Jul 4;2(3). pii: E21.
10.3390/jof2030021
2309-608X
2309-608X
Journal of fungi (Basel, Switzerland)
29376938
http://hdl.handle.net/20.500.12105/8967
Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting.
eng
Aspergillus fumigatus
Aspergillosis
Azole drug resistance
cyp51A
Mutations
Triazole Resistance in Aspergillus spp.: A Worldwide Problem?
journal article
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TriazoleResistanceInAspergillus_2016.pdf
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TriazoleResistanceInAspergillus_2016.pdf.txt