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oai:repisalud.isciii.es:20.500.12105/89652024-09-27T21:53:09Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Trevijano-Contador, Nuria author Zaragoza, Oscar author 2018-12-26 In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host⁻pathogen interactions. In recent years, the use of Galleria mellonella larvae, an insect belonging to the Lepidoptera order, has emerged as an excellent model to study the virulence of human pathogens. It is a model that offers many advantages; for example, it is easy to handle and establish in every laboratory, the larvae have a low cost, and they tolerate a wide range of temperatures, including human temperature 37 °C. The immune response of G. mellonella is innate and is divided into a cellular component (hemocytes) and humoral component (antimicrobial peptides, lytic enzymes, and peptides and melanin) that work together against different intruders. It has been shown that the immune response of this insect has a great specificity and has the ability to distinguish between different classes of microorganisms. In this review, we delve into the different components of the innate immune response of Galleria mellonella, and how these components manifest in the infection of fungal pathogens including Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Histoplasma capsulatum. J Fungi (Basel). 2018 Dec 26;5(1). pii: E3. 10.3390/jof5010003 2309-608X 2309-608X Journal of fungi (Basel, Switzerland) 30587801 http://hdl.handle.net/20.500.12105/8965 Galleria mellonella Cellular response Fungal pathogens Humoral response Innate immunity Immune Response of Galleria mellonella against Human Fungal Pathogens