2026-04-26T23:29:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89622024-09-27T22:14:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Perez-Olmeda, Mayte
author
Sánchez-Seco, María Paz
author
Vazquez, Ana
author
Balfagon, Pilar
author
Fuente, Jesus de la
author
Murillo, Maria Angeles
author
Minguito, Teodora
author
De Ory, Fernando de
funder
Instituto de Salud Carlos III
2020-01-29T11:44:36Z
2020-01-29T11:44:36Z
2020-01-07
Viruses. 2020 Jan 7;12(1). pii: E69.
1999-4915
http://hdl.handle.net/20.500.12105/8962
31936013
10.3390/v12010069
1999-4915
Viruses
The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples), dengue (DENV; 10 samples), chikungunya (CHIK V; 11 samples), rubella (RUBV; 10 samples) and measles (MeV; 10 samples) viruses, as well as human parvovirus B19 (HPVB19; 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laboratory results (PCR and a plaque-reduction neutralization test). The LIAISON showed excellent sensitivity (100%). The specificity (91.25%) was hampered by some false-positive results in recent dengue virus, chikungunya virus, measles virus and human parvovirus B19 infections. The method evaluated is adequate, but the low specificity makes it necessary to consider the clinical and epidemiological contexts of patients, as well as other laboratory results.
eng
Zika virus
Chemiluminescent immunoassay
Chikungunya virus
Dengue viruses
Enzyme immunoassay
Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections
research article
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EvaluationOfTheLIAISON_2020..pdf
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https://repisalud.isciii.es/bitstreams/919ab2b4-3ced-425e-af21-9021e16f32b5/download
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EvaluationOfTheLIAISON_2020..pdf.txt