2026-05-22T16:46:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89612024-11-29T12:10:56Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16988
Repisalud
author
Blanco, José Ramón
author
Alejos, Belén
author
Moreno, Santiago
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-01-29T11:44:21Z
2020-01-29T11:44:21Z
2020
PLoS One. 2020 Jan 16;15(1):e0226724.
10.1371/journal.pone.0226724
1932-6203
1932-6203
PloS one
31945066
http://hdl.handle.net/20.500.12105/8961
BACKGROUND: Multiple T-cell marker recovery (MTMR: CD4+ T-cells >500 cel/mm3 plus CD4+% >29% plus CD4+/CD8+ ratio >1) has been proposed as the most complete level of immune reconstitution. In this study we quantified differences in the CD4+/CD8+ ratio, CD4+% recovery and MTMR after starting HIV-1 treatment with dolutegravir (DTG) vs. raltegravir (RAL) plus a NRTI backbone. METHODS: Exploratory post-hoc analysis of the SPRING-2 study, a randomized double-blind clinical trial comparing DTG and RAL as third agents in naive HIV-infected patients at 100 sites in Canada, USA, Australia, and Europe. Percentage differences and corresponding precision based on 95% confidence intervals (CI) and p-values were calculated for i) CD4+/CD8+ ratio normalization, ii) CD4+% normalization, and iii) the achievement of MTMR. RESULTS: A total of 822 participants were analyzed (411 in each group). No statistically significant differences in the proportion of patients who reached a CD4+/CD8+ ratio ≥0.5 & ≥1 at w48 & w96 were observed. At w96, the proportion of patients with a CD4+/CD8+ ratio ≥1 was similar (30.43% DTG vs. 29.57% RAL). No differences were observed in the mean increase in CD4+/CD8+ ratio from baseline at both w48 & w96. Similarly, no significant differences in the CD4+/CD8+>29% were observed at w96 (72.95% DTG vs 69.28% RAL). The proportion of patients attaining MTMR criteria was also similar in the DTG group and the RAL group at w48 (20.33% vs. 18.26%; difference 2.07 (95%CI (-3.67;7.81) P = 0.481 and w96 (28.70% vs. 27.13; difference 1.56 (95%CI -5.22;8.34) P = 0.652). CONCLUSION: After comparing DTG and RAL, no differences on immune recovery markers were observed.
eng
Immune recovery markers in a double blind clinical trial comparing dolutegravir and raltegravir based regimens as initial therapy (SPRING-2)
journal article
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URL
https://repisalud.isciii.es/bitstreams/3f5b5103-2566-4537-a104-948d7eea82e6/download
File
MD5
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application/pdf
ImmuneRecoveryMarkersIn_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/d768f9c6-a462-42ad-804b-cce169219f1f/download
File
MD5
bc7796240d500f866bb1055e4c405642
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text/plain
ImmuneRecoveryMarkersIn_2020.pdf.txt