2026-06-14T05:05:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89602025-06-09T09:39:15Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Pérez-Cabezas, Begoña
author
Cecílio, Pedro
author
Robalo, Ana Luisa
author
Silvestre, Ricardo
author
Carrillo, Eugenia
author
Moreno, Javier
author
San Martín, Juan Víctor
author
Vasconcellos, Rita
author
Cordeiro-da-Silva, Anabela
funder
Unión Europea. Comisión Europea
funder
Fundação para a Ciência e Tecnologia (Portugal)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea
2020-01-29T11:44:05Z
2020-01-29T11:44:05Z
2016
Front Immunol. 2016 Nov 4;7:478. eCollection 2016.
10.3389/fimmu.2016.00478
1664-3224
Frontiers in immunology
27867384
http://hdl.handle.net/20.500.12105/8960
The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-γ+ splenic T cells, while administration of IL-27 to C57BL/6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation.
eng
IL-27
Leishmania infantum
Human
Immune regulation
Mouse models
Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans
research article
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Interleukin27EarlyImpacts_2016.pdf
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Interleukin27EarlyImpacts_2016.pdf.txt