2026-06-08T14:18:28Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/89082025-05-12T11:03:13Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Cullen, Elizabeth author Evans, David author Griffin, Chris author Burke, Padraig author Mannion, Rory author Burns, Damien author Flanagan, Andrew author Kellegher, Ann author Schoeters, Greet author Govarts, Eva author Biot, Pierre author Casteleyn, Ludwine author Castaño, Argelia author Kolossa-Gehring, Marike author Esteban-Lopez, Marta author Schwedler, Gerda author Koch, Holger M author Angerer, Jürgen author Knudsen, Lisbeth E author Joas, Reinhard author Joas, Anke author Dumez, Birgit author Sepai, Ovnair author Exley, Karen author Aerts, Dominique author 2017 Background: Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the 'Demonstration of a study to Co-ordinate and Perform Human Biomonitoring on a European Scale' (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents from families with lower educational attainment and in those exposed to such items as polyvinyl chloride (PVC), fast food and personal care products (PCP). Conclusions: The study demonstrates that human biomonitoring for assessing exposure to phthalates can be undertaken in Ireland and that the exposure of the population is widespread. Further work will be necessary before the consequences of this exposure are understood. Int J Environ Res Public Health. 2017 Nov 25;14(12). pii: E1456. 10.3390/ijerph14121456 1660-4601 1660-4601 International journal of environmental research and public health 29186834 http://hdl.handle.net/20.500.12105/8908 Endocrine disruptors Exposure Human biomonitoring Phthalates Urinary Phthalate Concentrations in Mothers and Their Children in Ireland: Results of the DEMOCOPHES Human Biomonitoring Study