2026-08-05T15:42:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/89042025-04-01T11:12:03Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19613col_20.500.12105_16959col_20.500.12105_16963col_20.500.12105_16967col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16983
Repisalud
author
Gutierrez-Gonzalez, Enrique
author
Castelló Pastor, Adela
author
Fernandez-Navarro, Pablo L
author
Castaño-Vinyals, Gemma
author
Llorca, Javier
author
Salas, Dolores
author
Salcedo-Bellido, Inmaculada
author
Aragones, Nuria
author
Fernández-Tardón, Guillermo
author
Alguacil, Juan
author
Gràcia-Lavedan, Esther
author
García-Esquinas, Esther
author
Gómez-Acebo, Inés
author
Amiano, Pilar
author
Romaguera, Dora
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Perez-Gomez, Beatriz
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Basque Government (España)
funder
Fundación Caja de Ahorros de Asturias
funder
University of Oviedo (España)
funder
Ministerio de Economía y Competitividad (España)
2020-01-16T07:55:30Z
2020-01-16T07:55:30Z
2018-12-20
Nutrients. 2018 Dec 20;11(1). pii: E18.
10.3390/nu11010018
2072-6643
2072-6643
Nutrients
http://hdl.handle.net/20.500.13003/8948
30577563
L625530909
2-s2.0-85058920971
http://hdl.handle.net/20.500.12105/8904
457474600054
Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake.
eng
Diet
Dietary zinc
Genetic susceptibility
Prostate cancer
Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
research article
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DietaryZincAndRisk_2018.pdf
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text/plain
DietaryZincAndRisk_2018.pdf.txt