2026-08-05T15:43:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/89042025-04-01T11:12:03Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19613col_20.500.12105_16959col_20.500.12105_16963col_20.500.12105_16967col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16983

00925njm 22002777a 4500 dc Gutierrez-Gonzalez, Enrique author Castelló Pastor, Adela author Fernandez-Navarro, Pablo L author Castaño-Vinyals, Gemma author Llorca, Javier author Salas, Dolores author Salcedo-Bellido, Inmaculada author Aragones, Nuria author Fernández-Tardón, Guillermo author Alguacil, Juan author Gràcia-Lavedan, Esther author García-Esquinas, Esther author Gómez-Acebo, Inés author Amiano, Pilar author Romaguera, Dora author Kogevinas, Manolis author Pollan-Santamaria, Marina author Perez-Gomez, Beatriz author 2018-12-20 Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake. Nutrients. 2018 Dec 20;11(1). pii: E18. 10.3390/nu11010018 2072-6643 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/8948 30577563 L625530909 2-s2.0-85058920971 http://hdl.handle.net/20.500.12105/8904 457474600054 Diet Dietary zinc Genetic susceptibility Prostate cancer Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study