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00925njm 22002777a 4500 dc Flores, José Carlos author Gràcia-Lavedan, Esther author Benavente, Yolanda author Amiano, Pilar author Romaguera, Dora author Costas, Laura author Robles, Claudia author Gonzalez-Barca, Eva author de la Banda, Esmeralda author Alonso, Esther author Aymerich, Marta author Campo, Elias author Dierssen-Sotos, Trinidad author Marcos-Gragera, Rafael author Rodríguez-Suárez, Marta María author Solans, Marta author Gimeno, Eva author Garcia Martin, Paloma author Aragones, Nuria author Shivappa, Nitin author Hebert, James R author Pollan-Santamaria, Marina author Kogevinas, Manolis author de Sanjose, Silvia author Castaño-Vinyals, Gemma author Casabonne, Delphine author 2019-12-23 Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research. Nutrients. 2019 Dec 23;12(1). pii: E48. 10.3390/nu12010048 2072-6643 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/12398 31878004 L2003420862 2-s2.0-85077310957 http://hdl.handle.net/20.500.12105/8903 516825500048 MCC Spain study Cancer Case-control study Chronic lymphocytic leukaemia Dietary inflammatory index Nutrition The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study