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oai:repisalud.isciii.es:20.500.12105/88942025-04-30T12:32:06Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16967col_20.500.12105_16978

00925njm 22002777a 4500 dc Jimenez-Sousa, Maria Angeles author Jiménez, José Luis author Fernandez-Rodriguez, Amanda author Brochado-Kith, Oscar author Bellón, José María author Gutierrez, Félix author Díez, Cristina author Bernal-Morell, Enrique author Viciana, Pompeyo author Muñoz-Fernández, María Ángeles author Resino, Salvador author 2019-03-05 BACKGROUND: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naïve HIV-infected patients. METHODS: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. RESULTS: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. CONCLUSIONS: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naïve HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes. J Clin Med. 2019 Mar 5;8(3). pii: E311. 10.3390/jcm8030311 2077-0383 Journal of clinical medicine http://hdl.handle.net/20.500.13003/17594 30841566 L2001809554 2-s2.0-85075189554 http://hdl.handle.net/20.500.12105/8894 464424500002 AIDS LTNPs VDR Non-progression Single nucleotide polymorphisms VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients