2026-06-14T03:31:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/88932024-09-27T21:03:12Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Lopez, Daniel
author
Barriga, Alejandro
author
Lorente, Elena
author
Mir-Gerrero, Carmen
funder
Ministerio de Economía y Competitividad (España)
2020-01-15T12:50:54Z
2020-01-15T12:50:54Z
2019-04-10
J Clin Med. 2019 Apr 10;8(4). pii: E486.
10.3390/jcm8040486
2077-0383
Journal of clinical medicine
30974886
http://hdl.handle.net/20.500.12105/8893
Accurate antiviral humoral and cellular immune responses require prior recognition of antigenic peptides presented by human leukocyte antigen (HLA) class I and II molecules on the surface of antigen-presenting cells. Both the helper and the cytotoxic immune responses are critical for the control and the clearance of human respiratory syncytial virus (HRSV) infection, which is a significant cause of morbidity and mortality in infected pediatric, immunocompromised and elderly populations. In this article we review the immunoproteomics studies which have defined the general antigen processing and presentation rules that determine both the immunoprevalence and the immunodominance of the cellular immune response to HRSV. Mass spectrometry and functional analyses have shown that the HLA class I and II cellular immune responses against HRSV are mainly focused on three viral proteins: fusion, matrix, and nucleoprotein. Thus, these studies have important implications for vaccine development against this virus, since a vaccine construct including these three relevant HRSV proteins could efficiently stimulate the major components of the adaptive immune system: humoral, helper, and cytotoxic effector immune responses.
eng
Antigen processing
HLA
T cells
Immune response
Immunoproteomics
Mass spectrometry
Respiratory infectious disease
Vaccine
Immunoproteomic Lessons for Human Respiratory Syncytial Virus Vaccine Design
journal article
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ImmunoproteomicLessonsForHuman_2019.pdf
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https://repisalud.isciii.es/bitstreams/d93691f9-51d6-43fe-b1ce-081d8aeada6d/download
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ImmunoproteomicLessonsForHuman_2019.pdf.txt