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oai:repisalud.isciii.es:20.500.12105/88932024-09-27T21:03:12Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Lopez, Daniel author Barriga, Alejandro author Lorente, Elena author Mir-Gerrero, Carmen author 2019-04-10 Accurate antiviral humoral and cellular immune responses require prior recognition of antigenic peptides presented by human leukocyte antigen (HLA) class I and II molecules on the surface of antigen-presenting cells. Both the helper and the cytotoxic immune responses are critical for the control and the clearance of human respiratory syncytial virus (HRSV) infection, which is a significant cause of morbidity and mortality in infected pediatric, immunocompromised and elderly populations. In this article we review the immunoproteomics studies which have defined the general antigen processing and presentation rules that determine both the immunoprevalence and the immunodominance of the cellular immune response to HRSV. Mass spectrometry and functional analyses have shown that the HLA class I and II cellular immune responses against HRSV are mainly focused on three viral proteins: fusion, matrix, and nucleoprotein. Thus, these studies have important implications for vaccine development against this virus, since a vaccine construct including these three relevant HRSV proteins could efficiently stimulate the major components of the adaptive immune system: humoral, helper, and cytotoxic effector immune responses. J Clin Med. 2019 Apr 10;8(4). pii: E486. 10.3390/jcm8040486 2077-0383 Journal of clinical medicine 30974886 http://hdl.handle.net/20.500.12105/8893 Antigen processing HLA T cells Immune response Immunoproteomics Mass spectrometry Respiratory infectious disease Vaccine Immunoproteomic Lessons for Human Respiratory Syncytial Virus Vaccine Design