2026-08-05T13:43:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/88502025-03-04T18:09:02Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud
author
Vigon-Hernandez, Lorena
author
Vázquez-Morón, Sonia
author
Berenguer, Juan
author
González-García, Juan
author
Jimenez-Sousa, Maria Angeles
author
Guardiola, Josep M
author
Crespo, Manuel
author
de Los Santos, Ignacio
author
Von Wichmann, Miguel A
author
Carrero, Ana
author
Yélamos, María Belén
author
Gómez, Julián
author
Resino, Salvador
author
Martinez, Isidoro
author
GESIDA 3603b Cohort Study Group
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
2019-12-20T11:49:12Z
2019-12-20T11:49:12Z
2019-08-21
Sci Rep. 2019 Aug 21;9(1):12163.
10.1038/s41598-019-48592-5
2045-2322
2045-2322
Scientific reports
31434968
http://hdl.handle.net/20.500.12105/8850
The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with peg-IFNα + ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against five JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVR.
eng
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR
research article
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File
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RapidDecreaseInTiter_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/3e4349d3-9977-40b8-a35e-30bbc47210af/download
File
MD5
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text/plain
RapidDecreaseInTiter_2019.pdf.txt