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00925njm 22002777a 4500 dc Vitelli-Storelli, Facundo author Molina, Antonio José author Zamora-Ros, Raúl author Fernández-Villa, Tania author Roussou, Vasiliki author Romaguera, Dora author Aragones, Nuria author Obón-Santacana, Mireia author Guevara, Marcela author Gómez-Acebo, Inés author Fernández-Tardón, Guillermo author Molina-Barceló, Ana author Olmedo-Requena, Rocío author Capelo, Rocío author Chirlaque, María-Dolores author Perez-Gomez, Beatriz author Moreno, Victor author Castilla Catalán, Jesús author Rubín-García, María author Pollan-Santamaria, Marina author Kogevinas, Manolis author Lera, Juan Pablo Barrio author Martín, Vicente author 2019-04-27 Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary. Nutrients. 2019 Apr 27;11(5). pii: E967. 10.3390/nu11050967 2072-6643 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/17131 31035601 L2001930355 2-s2.0-85065495437 http://hdl.handle.net/20.500.12105/8825 471021600027 MCC-Spain Case-control study Flavonoids Gastric cancer Intake Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study