2026-05-17T00:20:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/88072025-02-27T14:34:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Bernabeu-Zornoza, Adela
author
Coronel Lopez, Raquel
author
Palmer, Charlotte
author
Monteagudo, Maria
author
Zambrano, Alberto
author
Liste-Noya, Isabel
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
2019-12-11T12:39:34Z
2019-12-11T12:39:34Z
2019-12
Neural Regen Res. 2019 Dec;14(12):2035-2042.
10.4103/1673-5374.262571
1673-5374
Neural regeneration research
31397330
http://hdl.handle.net/20.500.12105/8807
Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer's disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β peptide and its role in Alzheimer's disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applications in diseases such as Alzheimer's disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possible molecular targets that could be implicated in these effects, especially GSK3β. A better understanding of amyloid-β peptide (both physiological and pathological), and the signaling pathways involved are essential to advance the field of Alzheimer's disease.
eng
Alzheimer's disease
Aβneural stem cells
GSK3β
Amyloid precursor protein
Amyloid-βpeptide
Gliogenesis
Neural progenitor cells
Neurogenesis
Toxicity
Physiological and pathological effects of amyloid-β species in neural stem cell biology
research article
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URL
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PhysiologicalPathologicalEffectsAmyloid_2019.pdf
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PhysiologicalAndPathologicalEffects_2019.pdf.txt
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PhysiologicalPathologicalEffectsAmyloid_2019.pdf.txt