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00925njm 22002777a 4500 dc Pelaez, T author Monteiro, Catia author Garcia-Rubio, Rocio author Gomez-Lopez, Alicia author Bouza, Emilio author Mellado, Emilia author 2015-07 We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance. New Microbes New Infect. 2015 Apr 20;6:33-4. 10.1016/j.nmni.2015.04.005 2052-2975 New microbes and new infections 26082842 http://hdl.handle.net/20.500.12105/8793 Aspergillus fumigatus Azole resistance spread cyp51A Resistance mechanism First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain