2026-06-14T03:29:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/87352025-05-14T12:18:58Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16982col_20.500.12105_19618
Repisalud
author
Cantón-Habas, Vanesa
author
Carrera-González, María Del Pilar
author
Moreno-Casbas, Teresa
author
Quesada-Gómez, José Manuel
author
Rich-Ruiz, Manuel
funder
Regional Government of Andalusia (España)
2019-12-03T12:55:07Z
2019-12-03T12:55:07Z
2019-11-10
BMJ Open. 2019 Nov 10;9(11):e032927
10.1136/bmjopen-2019-032927
2044-6055
2044-6055
BMJ open
31712347
http://hdl.handle.net/20.500.12105/8735
INTRODUCTION: Pain is an under-diagnosed problem in elderly people, especially in those with cognitive impairment who are unable to verbalise their pain. Although the Pain assessment in advanced dementia scale (PAINAD) scale is a tool recognised for its clinical interest in this type of patients, its correlation with the saliva biomarkers reinforced its utility. The aim of this research will be to correlate the scores of this scale with the levels of biomarkers of pain found in saliva samples of patients with cognitive impairment and inability to communicate. METHODS AND ANALYSIS: This is an observational study. The level of pain will be evaluated using the PAINAD scale. Moreover, pain biomarkers, in particular secretory IgA and soluble tumour necrosis factor receptor type II, will be determined in saliva. Both assessments will be conducted in 75 patients aged over 65 years with advanced cognitive impairment and inability to communicate. The PAINAD scores will be correlated with the levels of these biomarkers of pain. A control group consisting of 75 healthy subjects aged over 65 years will be included in the study. Moreover, sociodemographic variables and variables related to pain, dementia and other clinical conditions will be recorded. The analysis will be performed with the statistical package SPSS V.22 and the software R. ETHICS AND DISSEMINATION: The study has been reviewed and approved by the Andalusian Human Research Ethics Committee. In addition, this study has been financed by the Junta de Andalucía through a regional health research fund (Research code: PI-0357-2017). The results will be actively disseminated trough a high-impact journal in our study area, conference presentations and social media.
eng
PAINAD
Biomarkers
Cognitive impairment
Dementia
Nursing
Pain
Correlation between biomarkers of pain in saliva and PAINAD scale in elderly people with cognitive impairment and inability to communicate: descriptive study protocol
research article
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CorrelationBetweenBiomarkersPain_2019.pdf
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CorrelationBetweenBiomarkersOf_2019.pdf.txt
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CorrelationBetweenBiomarkersPain_2019.pdf.txt