2026-06-14T12:12:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/87322024-09-27T21:55:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Monge-Maillo, Begoña
author
Norman, Francesca F
author
Cruz, Israel
author
Alvar, Jorge
author
López-Vélez, Rogelio
2019-12-02T13:16:10Z
2019-12-02T13:16:10Z
2014-08
PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3021.
10.1371/journal.pntd.0003021
1935-2735
1935-2735
PLoS neglected tropical diseases
25144380
http://hdl.handle.net/20.500.12105/8732
Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region.
eng
Visceral leishmaniasis and HIV coinfection in the Mediterranean region
journal article
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URL
https://repisalud.isciii.es/bitstreams/2db90c08-3d3e-417e-add9-0f9c69fc7178/download
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VisceralLeishmaniasisAndHIV_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/9bc9d8ad-57f6-4f1c-869c-c41e1dce4174/download
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VisceralLeishmaniasisAndHIV_2014.pdf.txt