2026-04-29T04:09:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/87112025-06-26T10:10:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Shcherbakova, Nadezhda S
author
Shalamova, Lyudmila A
author
Delgado, Elena
author
Fernandez-Garcia, Aurora
author
Vega Rocha, Yolanda
author
Karpenko, Larissa I
author
Ilyichev, Alexander A
author
Sokolov, Yuri V
author
Shcherbakov, Dmitry N
author
Perez-Alvarez, Lucia
author
Thomson, Michael M
2019-11-26T08:01:17Z
2019-11-26T08:01:17Z
2014-09
AIDS Res Hum Retroviruses. 2014 Sep;30(9):912-9. doi: 10.1089/AID.2014.0075. Epub 2014 Aug 14.
http://hdl.handle.net/20.500.12105/8711
25050828
10.1089/AID.2014.0075
1931-8405
AIDS research and human retroviruses
The HIV-1 epidemic in Russia is dominated by the former Soviet Union subtype A (A(FSU)) variant, but other genetic forms are circulating in the country. One is the recently described CRF63_02A1, derived from recombination between a CRF02_AG variant circulating in Central Asia and A(FSU), which has spread in the Novosibirsk region, Siberia. Here we phylogenetically analyze pol and env segments from 24 HIV-1 samples from the Novosibirsk region collected in 2013, with characterization of three new near full-length genome CRF63_02A1 sequences, and estimate the time of the most recent common ancestor (tMRCA) and the demographic growth of CRF63_02A1 using a Bayesian method. The analyses revealed that CRF63_02A1 is highly predominant in the Novosibirsk region (81.2% in pol sequences) and is transmitted both among injecting drug users and by heterosexual contact. Similarity searches with database sequences combined with phylogenetic analyses show that CRF63_02A1 is circulating in East Kazakhstan and the Eastern area of Russia bordering China. The analyses of near full-length genome sequences show that its mosaic structure is more complex than reported, with 18 breakpoints. The tMRCA of CRF63_02A1 was estimated around 2006, with exponential growth in 2008-2009 and subsequent stabilization. These results provide new insights into the molecular epidemiology, phylogeny, and phylodynamics of CRF63_02A1.
eng
Molecular epidemiology, phylogeny, and phylodynamics of CRF63_02A1, a recently originated HIV-1 circulating recombinant form spreading in Siberia
research article
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URL
https://repisalud.isciii.es/bitstreams/55f782b4-ffa6-414f-91a6-f59e2c80afc7/download
File
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MolecularEpidemiologyPhylogenyAnd_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/88bf5836-bbc9-4f0c-ac5f-9ffdf4450bfe/download
File
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MolecularEpidemiologyPhylogenyAnd_2014.pdf.txt