2026-06-14T03:32:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/86942025-04-29T13:38:18Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958col_20.500.12105_16977
Repisalud
author
Restrepo, Clara
author
Gutiirrez-Rivas, Monica
author
Pacheco, Yolanda María
author
García, Marcial
author
Blanco, Julià
author
Medrano, Luz Maria
author
Navarrete-Muñoz, María A
author
Gutiérrez, Félix
author
Miralles, Pilar
author
Dalmau, David
author
Gómez, Juan Luis
author
Górgolas, Miguel
author
Cabello, Alfonso
author
Resino, Salvador
author
Benito, José Miguel
author
Rallón, Norma
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-11-25T12:45:06Z
2019-11-25T12:45:06Z
2019
PLoS One. 2019 Mar 28;14(3):e0214421.
10.1371/journal.pone.0214421
1932-6203
1932-6203
PloS one
30921390
http://hdl.handle.net/20.500.12105/8694
OBJECTIVE: We investigated the association of genetic polymorphisms in chemokine and chemokine receptor genes with poor immunological recovery in HIV patients starting combined antiretroviral therapy (cART) with low CD4 T-cell counts. METHODS: A case-control study was conducted in 412 HIV-infected patients starting cART with CD4 T-cell count <200 cells/μL and successful viral control for two years. CD4 count increase below 200 cells/μL after two years on cART was used to define INR (immunological non-responder) patients. Polymorphisms in CXCL12, CCL5 and CCR2 genes were genotyped using sequenom's MassARRAY platform. RESULTS: Thirty two percent (134/412) of patients were classified as INR. After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06). CONCLUSIONS: CCR2 rs1799864-AG or CXCL12 rs1801157-TT genotypes influence on the probability of poor CD4 recovery in the population of HIV patients starting cART with low CD4 counts. Genotyping of these polymorphisms could be used to estimate the risk of poor CD4 restoration, mainly in patients who are diagnosed late in the course of infection.
eng
Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression
research article
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URL
https://repisalud.isciii.es/bitstreams/00c3ebef-7188-41f0-baf1-3483cbf23147/download
File
MD5
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application/pdf
GeneticVariationInCCR2_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/a128f887-cecf-437b-9351-d0ab9d9a50c3/download
File
MD5
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text/plain
GeneticVariationInCCR2_2019.pdf.txt