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oai:repisalud.isciii.es:20.500.12105/86942025-04-29T13:38:18Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958col_20.500.12105_16977

00925njm 22002777a 4500 dc Restrepo, Clara author Gutiirrez-Rivas, Monica author Pacheco, Yolanda María author García, Marcial author Blanco, Julià author Medrano, Luz Maria author Navarrete-Muñoz, María A author Gutiérrez, Félix author Miralles, Pilar author Dalmau, David author Gómez, Juan Luis author Górgolas, Miguel author Cabello, Alfonso author Resino, Salvador author Benito, José Miguel author Rallón, Norma author 2019 OBJECTIVE: We investigated the association of genetic polymorphisms in chemokine and chemokine receptor genes with poor immunological recovery in HIV patients starting combined antiretroviral therapy (cART) with low CD4 T-cell counts. METHODS: A case-control study was conducted in 412 HIV-infected patients starting cART with CD4 T-cell count <200 cells/μL and successful viral control for two years. CD4 count increase below 200 cells/μL after two years on cART was used to define INR (immunological non-responder) patients. Polymorphisms in CXCL12, CCL5 and CCR2 genes were genotyped using sequenom's MassARRAY platform. RESULTS: Thirty two percent (134/412) of patients were classified as INR. After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06). CONCLUSIONS: CCR2 rs1799864-AG or CXCL12 rs1801157-TT genotypes influence on the probability of poor CD4 recovery in the population of HIV patients starting cART with low CD4 counts. Genotyping of these polymorphisms could be used to estimate the risk of poor CD4 restoration, mainly in patients who are diagnosed late in the course of infection. PLoS One. 2019 Mar 28;14(3):e0214421. 10.1371/journal.pone.0214421 1932-6203 1932-6203 PloS one 30921390 http://hdl.handle.net/20.500.12105/8694 Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression