2026-05-22T00:05:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85902025-04-01T10:18:46Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16967col_20.500.12105_16970col_20.500.12105_16985col_20.500.12105_16972col_20.500.12105_16988
Repisalud
author
Oteo-Iglesias, Jesus
author
Ortega, Adriana
author
Bartolomé, Rosa
author
Bou, Germán
author
Conejo, María Carmen
author
Fernández-Martínez, Marta
author
González-López, Juan José
author
Martínez-García, Laura
author
Martínez-Martínez, Luis
author
Merino, María
author
Miró, Elisenda
author
Mora, Marta
author
Navarro, Ferran
author
Oliver, Antonio
author
Pascual, Álvaro
author
Rodríguez-Baño, Jesús
author
Ruiz-Carrascoso, Guillermo
author
Ruiz-Garbajosa, Patricia
author
Zamorano, Laura
author
Bautista, Veronica
author
Perez-Vazquez, Maria
author
Campos, Jose
funder
Instituto de Salud Carlos III
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-11-14T10:53:22Z
2019-11-14T10:53:22Z
2015
Antimicrob Agents Chemother. 2015;59(6):3406-12.
10.1128/AAC.00086-15
1098-6596
0066-4804
Antimicrobial agents and chemotherapy
25824224
http://hdl.handle.net/20.500.12105/8590
The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing the prevalence, dissemination, and geographic distribution of CPE clones, and their population structure and antibiotic susceptibility. From February 2013 to May 2013, 83 hospitals (about 40,000 hospital beds) prospectively collected nonduplicate Enterobacteriaceae using the screening cutoff recommended by EUCAST. Carbapenemase characterization was performed by phenotypic methods and confirmed by PCR and sequencing. Multilocus sequencing types (MLST) were determined for Klebsiella pneumoniae and Escherichia coli. A total of 702 Enterobacteriaceae isolates met the inclusion criteria; 379 (54%) were CPE. OXA-48 (71.5%) and VIM-1 (25.3%) were the most frequent carbapenemases, and K. pneumoniae (74.4%), Enterobacter cloacae (10.3%), and E. coli (8.4%) were the species most affected. Susceptibility to colistin, amikacin, and meropenem was 95.5%, 81.3%, and 74.7%, respectively. The most prevalent sequence types (STs) were ST11 and ST405 for K. pneumoniae and ST131 for E. coli. Forty-five (54.1%) of the hospitals had at least one CPE case. For K. pneumoniae, ST11/OXA-48, ST15/OXA-48, ST405/OXA-48, and ST11/VIM-1 were detected in two or more Spanish provinces. ST11 isolates carried four carbapenemases (VIM-1, OXA-48, KPC-2, and OXA-245), but ST405 isolates carried OXA-48 only. A wide interregional spread of CPE in Spain was observed, mainly due to a few successful clones of OXA-48-producing K. pneumoniae (e.g., ST11 and ST405). The dissemination of OXA-48-producing E. coli is a new finding of public health concern. According to the susceptibilities determined in vitro, most of the CPE (94.5%) had three or more options for antibiotic treatment.
eng
Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem
research article
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ProspectiveMulticenterStudyOf_2015.pdf
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https://repisalud.isciii.es/bitstreams/287adab3-0c34-4391-8f76-e35ebd0e5d77/download
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text/plain
ProspectiveMulticenterStudyOf_2015.pdf.txt