2026-06-14T03:29:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85832024-09-27T22:56:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Lorente, Elena
author
Garcia, Ruth
author
Lopez, Daniel
funder
Fundación para la Investigación y la Prevención del Sida en España
2019-11-14T09:35:24Z
2019-11-14T09:35:24Z
2011-11-04
J Biol Chem. 2011 Nov 4;286(44):38054-9. doi: 10.1074/jbc.M111.281808. Epub 2011 Sep 13.
10.1074/jbc.M111.281808
1083-351X
0021-9258
The Journal of biological chemistry
21914809
http://hdl.handle.net/20.500.12105/8583
The transporters associated with antigen processing (TAP) allow the supply of peptides derived from the cytosol to translocate to the endoplasmic reticulum, where they complex with nascent human leukocyte antigen (HLA) class I molecules. However, infected and tumor cells with TAP molecules blocked or individuals with nonfunctional TAP complexes are able to present HLA class I ligands generated by TAP-independent processing pathways. These peptides are detected by the CD8(+) lymphocyte cellular response. Here, the generation of the overall peptide repertoire associated with four different HLA class I molecules in TAP-deficient cells was studied. Using different protease inhibitors, four different proteolytic specificities were identified. These data demonstrate the different allele-dependent complex processing pathways involved in the generation of the HLA class I peptide repertoire in TAP-deficient cells.
eng
Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells
journal article
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AlleleDependentProcessingPathways_2011.pdf
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AlleleDependentProcessingPathways_2011.pdf.txt