2026-07-22T07:59:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85812024-09-27T09:47:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Penela, Petronila
author
Ribas, Catalina
author
Sanchez-Madrid, Francisco
author
Mayor, Federico
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
2019-11-14T08:15:16Z
2019-11-14T08:15:16Z
2019-11
Cell Mol Life Sci. 2019; 76(22):4423-4446
10.1007/s00018-019-03274-3
1420-9071
1420-682X
Cellular and molecular life sciences : CMLS
31432234
http://hdl.handle.net/20.500.12105/8581
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.
eng
GPCR
GRK2
HDAC6
Interactome
Phosphorylation
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub
journal article
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URL
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File
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Gprotein-coupledReceptorKlinase_2019.pdf
URL
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Gprotein-coupledReceptorKlinase_2019.pdf.txt