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00925njm 22002777a 4500 dc Penela, Petronila author Ribas, Catalina author Sanchez-Madrid, Francisco author Mayor, Federico author 2019-11 Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts. Cell Mol Life Sci. 2019; 76(22):4423-4446 10.1007/s00018-019-03274-3 1420-9071 1420-682X Cellular and molecular life sciences : CMLS 31432234 http://hdl.handle.net/20.500.12105/8581 GPCR GRK2 HDAC6 Interactome Phosphorylation G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub