2026-06-14T05:06:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85692024-09-27T20:53:32Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rodriguez-Garcia, Mercedes
author
Boros, Peter
author
Bromberg, Jonathan S
author
Ochando, Jordi
funder
Ministerio de Educación y Ciencia (España)
funder
Instituto de Salud Carlos III
2019-11-08T12:18:55Z
2019-11-08T12:18:55Z
2010-08
Curr Opin Organ Transplant. 2010 Aug;15(4):416-21. doi: 10.1097/MOT.0b013e32833bcf5e.
10.1097/MOT.0b013e32833bcf5e
1531-7013
1087-2418
Current opinion in organ transplantation
20616727
http://hdl.handle.net/20.500.12105/8569
PURPOSE OF REVIEW: Understanding the interplay between myeloid dendritic cells and T cells under tolerogenic conditions, and whether their interactions induce the development of antigen-specific regulatory T cells (Tregs) is critical to uncover the mechanisms involved in the induction of indefinite allograft survival. RECENT FINDINGS: Myeloid dendritic cell-T-cell interactions are seminal events that determine the outcome of the immune response, and multiple in-vitro protocols suggest the generation of tolerogenic myeloid dendritic cells that modulate T-cell responses, and determine the outcome of the immune response to an allograft following adoptive transfer. We believe that identifying specific conditions that lead to the generation of tolerogenic myeloid dendritic cells and Tregs are critical for the manipulation of the immune response towards the development of transplantation tolerance. SUMMARY: We summarize recent findings regarding specific culture conditions that generate tolerogenic myeloid dendritic cells that induce T-cell hyporesponsiveness and Treg development, which represents a novel immunotherapeutic approach to promote the induction of indefinite graft survival prolongation. The interpretations presented here illustrate that different mechanisms govern the generation of tolerogenic myeloid dendritic cells, and we discuss the concomitant therapeutic implications.
eng
Immunotherapy with myeloid cells for tolerance induction
journal article
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URL
https://repisalud.isciii.es/bitstreams/a49eca46-8d7d-4169-9adc-e61928ab3a2c/download
File
MD5
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application/pdf
ImmunotherapyWithyelMyeloidCells_2010.pdf
URL
https://repisalud.isciii.es/bitstreams/b4f19b8c-c027-4539-b157-ef6baebe0f36/download
File
MD5
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text/plain
ImmunotherapyWithyelMyeloidCells_2010.pdf.txt