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Repisalud author Liu, Jingjing author Lončar, Ivona author Collée, J Margriet author Bolla, Manjeet K author Dennis, Joe author Michailidou, Kyriaki author Wang, Qin author Andrulis, Irene L author Barile, Monica author Beckmann, Matthias W author Behrens, Sabine author Benitez, Javier author Blomqvist, Carl author Boeckx, Bram author Bogdanova, Natalia V author Bojesen, Stig E author Brauch, Hiltrud author Brennan, Paul author Brenner, Hermann author Broeks, Annegien author Burwinkel, Barbara author Chang-Claude, Jenny author Chen, Shou-Tung author Chenevix-Trench, Georgia author Cheng, Ching Y author Choi, Ji-Yeob author Couch, Fergus J author Cox, Angela author Cross, Simon S author Cuk, Katarina author Czene, Kamila author Dörk, Thilo author Dos-Santos-Silva, Isabel author Fasching, Peter A author Figueroa, Jonine author Flyger, Henrik author García-Closas, Montserrat author Giles, Graham G author Glendon, Gord author Goldberg, Mark S author Gonzalez Neira, Anna author Guénel, Pascal author Haiman, Christopher A author Hamann, Ute author Hart, Steven N author Hartman, Mikael author Hatse, Sigrid author Hopper, John L author Ito, Hidemi author Jakubowska, Anna author Kabisch, Maria author Kang, Daehee author Kosma, Veli-Matti author Kristensen, Vessela N author Le Marchand, Loic author Lee, Eunjung author Li, Jingmei author Lophatananon, Artitaya author Jan Lubinski, null author Mannermaa, Arto author Matsuo, Keitaro author Milne, Roger L author Neuhausen, Susan L author Nevanlinna, Heli author Orr, Nick author Perez, Jose I A author Peto, Julian author Putti, Thomas C author Pylkäs, Katri author Radice, Paolo author Sangrajrang, Suleeporn author Sawyer, Elinor J author Schmidt, Marjanka K author Schneeweiss, Andreas author Shen, Chen-Yang author Shrubsole, Martha J author Shu, Xiao-Ou author Simard, Jacques author Southey, Melissa C author Swerdlow, Anthony author Teo, Soo H author Tessier, Daniel C author Thanasitthichai, Somchai author Tomlinson, Ian author Torres, Diana author Truong, Thérèse author Tseng, Chiu-Chen author Vachon, Celine author Winqvist, Robert author Wu, Anna H author Yannoukakos, Drakoulis author Zheng, Wei author Hall, Per author Dunning, Alison M author Easton, Douglas F author Hooning, Maartje J author van den Ouweland, Ans M W author Martens, John W M author Hollestelle, Antoinette funder Unión Europea. Comisión Europea. European Research Council (ERC) funder United States Department of Health and Human Services funder Post-cancer GWAS Initiative funder Dutch Cancer Society (Holanda) funder NIH - National Cancer Institute (NCI) (Estados Unidos) funder Instituto de Salud Carlos III funder California Breast Cancer Research Program funder California Department of Public Health funder Lon V. Smith Foundation funder Federal Ministry of Education & Research (Alemania) funder Finlands Akademi (Finlandia) funder Ministry of Education, Culture, Sports, Science, and Technology (Japón) funder Japan Agency for Medical Research and Development funder United States Army Medical Research and Development Command funder National Health and Medical Research Council (Australia) funder Deutsche Krebshilfe funder Quebec Breast Cancer Foundation funder Canadian Institutes of Health Research funder Ministry of Higher Education (Malasia) funder The Research Council of Norway funder Southern and Eastern Norway Regional Health Authority funder Norwegian Cancer Society funder Survey and Biospecimen Shared Resource funder Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative funder BRL (Basic Research Laboratory) program through the National Research Foundation of Korea - Ministry of Education, Science and Technology funder Agency for Science, Technology and Research (Singapur) funder NIH - National Cancer Institute (NCI). Specialized Programs of Research Excellence (SPOREs) (Estados Unidos) funder Hellenic Cooperative Oncology Group funder Cancer Research UK (Reino Unido) 2019-11-04T13:04:10Z 2019-11-04T13:04:10Z 2016 Sci Rep. 2016 ;6:36874 2045-2322 http://hdl.handle.net/20.500.12105/8558 27845421 10.1038/srep36874 2045-2322 Scientific reports NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility. eng rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk journal article 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 URL https://repisalud.isciii.es/bitstreams/d885e158-2d30-43fe-817f-366b3b2beee9/download File MD5 083c3a369a753211cf1d7a08e544041d 686166 application/pdf rs2735383located at a microRNA_2016.pdf URL https://repisalud.isciii.es/bitstreams/7a7a4a7e-91bf-4fa1-b78b-cb32f391beb6/download File MD5 44df6a60a2c3920b6f9f8b76118c24d4 194263 application/pdf s2735383locatedatamicroRNA_2016.pdf URL https://repisalud.isciii.es/bitstreams/1c9f3d77-62c5-412d-8f53-339a0a5090fd/download File MD5 c3c1dc15216030b4a1e6df9ee7bbb3e9 71383 text/plain rs2735383located at a microRNA_2016.pdf.txt URL https://repisalud.isciii.es/bitstreams/5c5f9fbd-29ee-49d1-8a95-db9ae7c0fd5a/download File MD5 a1dc1b1840fb689907c2e9b30cb28d66 52717 text/plain s2735383locatedatamicroRNA_2016.pdf.txt