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00925njm 22002777a 4500 dc Castelló Pastor, Adela author Amiano, Pilar author Fernandez de Larrea-Baz, Nerea author Martín, Vicente author Alonso, María Henar author Castaño-Vinyals, Gemma author Perez-Gomez, Beatriz author Olmedo-Requena, Rocío author Guevara, Marcela author Fernández-Tardón, Guillermo author Dierssen-Sotos, Trinidad author Llorens-Ivorra, Cristóbal author Huerta, José María author Capelo, Rocío author Fernández-Villa, Tania author Díez-Villanueva, Anna author Urtiaga, Carmen author Castilla Catalán, Jesús author Jimenez-Moleon, Jose J. author Moreno, Victor author Dávila-Batista, Verónica author Kogevinas, Manolis author Aragones, Nuria author Pollan-Santamaria, Marina author 2019-06 PURPOSE: To assess if the associations found between three previously identified dietary patterns with breast, prostate and gastric cancer are also observed for colorectal cancer (CRC). METHODS: MCC-Spain is a multicase-control study that collected information of 1629 incident cases of CRC and 3509 population-based controls from 11 Spanish provinces. Western, Prudent and Mediterranean data-driven dietary patterns-derived in another Spanish case-control study-were reconstructed in MCC-Spain. Their association with CRC was assessed using mixed multivariable logistic regression models considering a possible interaction with sex. Risk by tumor site (proximal colon, distal colon, and rectum) was evaluated using multinomial regression models. RESULTS: While no effect of the Prudent pattern on CRC risk was observed, a high adherence to the Western dietary pattern was associated with increased CRC risk for both males [ORfourth(Q4) vs. first(Q1)quartile (95% CI): 1.45 (1.11;1.91)] and females [ORQ4 vs. Q1 (95% CI): 1.50 (1.07;2.09)] but seem to be confined to distal colon [ORfourth(Q4) vs. first(Q1)quartile (95% CI): 2.02 (1.44;2.84)] and rectal [ORQ4 vs. Q1 (95% CI): 1.46 (1.05;2.01)] tumors. The protective effect of the Mediterranean dietary pattern against CRC was observed for both sexes [males: ORQ4 vs. Q1 (95% CI): 0.71 (0.55;0.92); females: ORQ4 vs. Q1 (95% CI): 0.56 (0.40;0.77)] and for all cancer sites: proximal colon [ORQ4 vs. Q1 (95% CI): 0.70 (0.51;0.97)], distal colon [ORQ4 vs. Q1 (95% CI): 0.65 (0.48;0.89)], and rectum (ORQ4 vs. Q1 (95% CI): 0.60 (0.45;0.81)]. CONCLUSION: Our results are consistent with most of the associations previously found between these patterns and breast, prostate and gastric cancer risk and indicate that consuming whole fruits, vegetables, legumes, olive oil, nuts, and fish and avoiding red and processed meat, refined grains, sweets, caloric drinks, juices, convenience food, and sauces might reduce CRC risk. Eur J Nutr. 2019 Jun;58(4):1495-1505. 10.1007/s00394-018-1674-5 1436-6215 1436-6207 European journal of nutrition 29582162 http://hdl.handle.net/20.500.12105/8551 Colonic neoplasms Diet Diet, Mediterranean Diet, Western Dietary patterns Prevention and control Principal component analysis Rectal neoplasms Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer