2026-04-29T07:21:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85402024-11-28T16:15:03Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
Herrero-Fernandez, Beatriz
author
Gomez-Bris, Raquel
author
Somovilla-Crespo, Beatriz
author
Gonzalez-Granado, Jose Maria
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Autonomous University of Madrid (España)
2019-10-31T10:49:53Z
2019-10-31T10:49:53Z
2019-10
Int J Mol Sci. 2019; 20(21):e5293
1422-0067
http://hdl.handle.net/20.500.12105/8540
31653058
10.3390/ijms20215293
1422-0067
International journal of molecular sciences
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction, intimal lipid deposition, smooth muscle cell proliferation, cell apoptosis and necrosis, and local and systemic inflammation, involving key contributions to from innate and adaptive immunity. The balance between proatherogenic inflammatory and atheroprotective anti-inflammatory responses is modulated by a complex network of interactions among vascular components and immune cells, including monocytes, macrophages, dendritic cells, and T, B, and foam cells; these interactions modulate the further progression and stability of the atherosclerotic lesion. In this review, we take a global perspective on existing knowledge about the pathogenesis of immune responses in the atherosclerotic microenvironment and the interplay between the major innate and adaptive immune factors in atherosclerosis. Studies such as this are the basis for the development of new therapies against atherosclerosis.
eng
B-cell
T-cell
Atherosclerosis
Conventional dendritic cell
Foam cell
Macrophage
Monocyte
Monocyte-derived dendritic cell
Plasmacytoid dendritic cell
Regulatory dendritic cell
Immunobiology of Atherosclerosis: A Complex Net of Interactions
journal article
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URL
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File
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ImmunobiologyAtherosclerosisComplexNet_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/77fd9a1b-d6b9-46e2-b4bf-b631ab066ed2/download
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ImmunobiologyAtherosclerosisComplexNet_2019.pdf.txt