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00925njm 22002777a 4500 dc Herrero-Fernandez, Beatriz author Gomez-Bris, Raquel author Somovilla-Crespo, Beatriz author Gonzalez-Granado, Jose Maria author 2019-10 Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction, intimal lipid deposition, smooth muscle cell proliferation, cell apoptosis and necrosis, and local and systemic inflammation, involving key contributions to from innate and adaptive immunity. The balance between proatherogenic inflammatory and atheroprotective anti-inflammatory responses is modulated by a complex network of interactions among vascular components and immune cells, including monocytes, macrophages, dendritic cells, and T, B, and foam cells; these interactions modulate the further progression and stability of the atherosclerotic lesion. In this review, we take a global perspective on existing knowledge about the pathogenesis of immune responses in the atherosclerotic microenvironment and the interplay between the major innate and adaptive immune factors in atherosclerosis. Studies such as this are the basis for the development of new therapies against atherosclerosis. Int J Mol Sci. 2019; 20(21):e5293 1422-0067 http://hdl.handle.net/20.500.12105/8540 31653058 10.3390/ijms20215293 1422-0067 International journal of molecular sciences B-cell T-cell Atherosclerosis Conventional dendritic cell Foam cell Macrophage Monocyte Monocyte-derived dendritic cell Plasmacytoid dendritic cell Regulatory dendritic cell Immunobiology of Atherosclerosis: A Complex Net of Interactions