2026-06-14T03:31:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/85392024-10-31T11:50:30Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Sande-Melon, Marcos author Marques, Ines Joao author Galardi-Castilla, Maria author Langa, Xavier author Pérez-López, María author Botos, Marius-Alexandru author Sanchez-Iranzo, Hector author Guzman-Martinez, Gabriela author Ferreira Francisco, David Miguel author Pavlinic, Dinko author Benes, Vladimir author Bruggmann, Rémy author Mercader, Nadia author 2019-10 During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration. Cell Rep. 2019; 29(4):1041-1054 10.1016/j.celrep.2019.09.041 2211-1247 22111247 Cell reports 31644901 http://hdl.handle.net/20.500.12105/8539 Cardiomyocyte proliferation Heart regeneration Sox10 Zebrafish Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish