2026-08-05T13:43:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85312025-05-16T11:23:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Zhang, Nan
author
Schröppel, Bernd
author
Lal, Girdhari
author
Jakubzick, Claudia
author
Mao, Xia
author
Chen, Dan
author
Yin, Na
author
Jessberger, Rolf
author
Ochando, Jordi
author
Ding, Yaozhong
author
Bromberg, Jonathan S
funder
Ministerio de Educación y Ciencia (España)
funder
National Institutes of Health (Estados Unidos)
funder
Alberta Emerald Foundation
2019-10-25T10:29:24Z
2019-10-25T10:29:24Z
2009-03-20
Immunity. 2009 Mar 20;30(3):458-69
10.1016/j.immuni.2008.12.022
1097-4180
1074-7613
Immunity
https://pmc.ncbi.nlm.nih.gov/articles/PMC2737741/
19303390
http://hdl.handle.net/20.500.12105/8531
To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR2, CCR5, and CCR7 fashion; this movement was essential for optimal suppression. Treg cells inhibited dendritic cell migration in a TGF-beta and IL-10 dependent fashion and suppressed antigen-specific T effector cell migration, accumulation, and proliferation in dLNs and allografts. These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function.
eng
Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
research article
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