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oai:repisalud.isciii.es:20.500.12105/85312025-05-16T11:23:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Zhang, Nan author Schröppel, Bernd author Lal, Girdhari author Jakubzick, Claudia author Mao, Xia author Chen, Dan author Yin, Na author Jessberger, Rolf author Ochando, Jordi author Ding, Yaozhong author Bromberg, Jonathan S author 2009-03-20 To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR2, CCR5, and CCR7 fashion; this movement was essential for optimal suppression. Treg cells inhibited dendritic cell migration in a TGF-beta and IL-10 dependent fashion and suppressed antigen-specific T effector cell migration, accumulation, and proliferation in dLNs and allografts. These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function. Immunity. 2009 Mar 20;30(3):458-69 10.1016/j.immuni.2008.12.022 1097-4180 1074-7613 Immunity https://pmc.ncbi.nlm.nih.gov/articles/PMC2737741/ 19303390 http://hdl.handle.net/20.500.12105/8531 Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response