2026-06-14T03:28:55Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/85102024-11-29T15:46:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Abascal, Federico author Corvelo, André author Cruz, Fernando author Villanueva-Cañas, José L author Vlasova, Anna author Marcet-Houben, Marina author Martínez-Cruz, Begoña author Cheng, Jade Yu author Prieto, Pablo author Quesada, Víctor author Quilez, Javier author Li, Gang author García, Francisca author Rubio-Camarillo, Miriam author Frias, Leonor author Ribeca, Paolo author Capella-Gutierrez, Salvador Jesus author Rodríguez, José M author Câmara, Francisco author Lowy, Ernesto author Cozzuto, Luca author Erb, Ionas author Tress, Michael L author Rodriguez-Ales, Jose L author Ruiz-Orera, Jorge author Reverter, Ferran author Casas-Marce, Mireia author Soriano, Laura author Arango, Javier R author Derdak, Sophia author Galán, Beatriz author Blanc, Julie author Gut, Marta author Lorente-Galdos, Belen author Andrés-Nieto, Marta author López-Otín, Carlos author Valencia, Alfonso author Gut, Ivo author García, José L author Guigó, Roderic author Murphy, William J author Ruiz-Herrera, Aurora author Marques-Bonet, Tomas author Roma, Guglielmo author Notredame, Cedric author Mailund, Thomas author Albà, M Mar author Gabaldón, Toni author Alioto, Tyler author Godoy, José A funder Banco Santander funder Unión Europea. Comisión Europea. 7 Programa Marco funder Ministerio de Economía y Competitividad (España) funder Institució Catalana de Recerca i Estudis Avançats funder Biotechnology and Biological Sciences Research Council (Reino Unido) 2019-10-21T11:22:12Z 2019-10-21T11:22:12Z 2016-12-14 Genome Biol. 2016 ;17(1):251. 10.1186/s13059-016-1090-1 1474-760X 1474-760X Genome biology 27964752 http://hdl.handle.net/20.500.12105/8510 BACKGROUND: Genomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction. RESULTS: We generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species. CONCLUSIONS: The genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species. eng Conservation genomics Genetic diversity Genetic drift Inbreeding Lynx Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx journal article TElDRU5DSUEgREUgRElTVFJJQlVDScOTTiBOTyBFWENMVVNJVkEKCkFjZXB0YW5kbyBlc3RhIGxpY2VuY2lhLCBVc3RlZCAoZWwgYXV0b3IvZXMgbyBlbCBwcm9waWV0YXJpby9zIGRlIGxvcyBkZXJlY2hvcyBkZSAKYXV0b3IpIGNvbmNlZGUgYSBSRVBJU0FMVUQgZWwgZGVyZWNobyBubyBleGNsdXNpdm8gZGUgcmVwcm9kdWNpciwgY29udmVydGlyLCB5L28gCmRpc3RyaWJ1aXIgc3UgZG9jdW1lbnRvIChpbmNsdXllbmRvIHN1IHJlc3VtZW4pIGEgbml2ZWwgbXVuZGlhbCBlbiBmb3JtYXRvIGRpZ2l0YWwsIAppbmNsdXllbmRvLCBhdWRpbyB5IHbDrWRlbywgYSB0cmF2w6lzIGRlIHN1IHJlcG9zaXRvcmlvIGluc3RpdHVjaW9uYWwuCgpVc3RlZCBhY2VwdGEgcXVlIFJFUElTQUxVRCBwdWVkZSwgc2luIGFsdGVyYXIgc3UgY29udGVuaWRvLCBjb252ZXJ0aXIgc3UgZG9jdW1lbnRvIAphIGN1YWxxdWllciBvdHJvIGZvcm1hdG8gZGlnaXRhbCBkZSBkYXRvcywgYXVkaW8geSB2aWRlbywgY29uIGVsIHByb3DDs3NpdG8gZGUgcXVlIApwdWVkYSBzZXIgYWxvamFkbyBlbiBlbCByZXBvc2l0b3Jpby4gCgpVc3RlZCBlc3TDoSBkZSBhY3VlcmRvIGNvbiBxdWUgUkVQSVNBTFVEIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBkZSBlc3RlIApkb2N1bWVudG8gcGFyYSBhc2VndXJhciBzdSBzZWd1cmlkYWQsIHByZXNlcnZhY2nDs24geSBhY2Nlc28uCgpVc3RlZCBkZWNsYXJhIHF1ZSBlbCBkb2N1bWVudG8gZXMgdW4gdHJhYmFqbyBvcmlnaW5hbCwgeSBxdWUgdGllbmUgZWwgZGVyZWNobyBkZSAKb3RvcmdhciBsb3MgZGVyZWNob3MgY29udGVuaWRvcyBlbiBlc3RhIGxpY2VuY2lhLiBUYW1iacOpbiBkZWNsYXJhIHF1ZSBzdSBwZXRpY2nDs24gCm5vIGluZnJpbmdlIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBkZSBuYWRpZS4gCgpTaSBlbCBkb2N1bWVudG8gY29udGllbmUgbWF0ZXJpYWxlcyBwYXJhIGxvcyBxdWUgbm8gc2UgdGllbmVuIGxvcyBkZXJlY2hvcyBkZSBhdXRvciwgClVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGVsIHBlcm1pc28gc2luIHJlc3RyaWNjacOzbiBkZWwgcHJvcGlldGFyaW8gZGUgbG9zIApkZXJlY2hvcyB5IHF1ZSBlbiBkaWNobyBtYXRlcmlhbCwgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZGEgeSByZWNvbm9jaWRhIHN1IAphdXRvcsOtYSBkZW50cm8gZWwgdGV4dG8gbyBkZWwgY29udGVuaWRvIGRlIGRpY2hvIGRvY3VtZW50by4gCgpTaSBlbCBlbnbDrW8gc2UgYmFzYSBlbiB1biB0cmFiYWpvIHF1ZSBoYSBzaWRvIHBhdHJvY2luYWRvIG8gYXBveWFkbyBwb3IgdW5hIGFnZW5jaWEgCnUgb3JnYW5pemFjacOzbiBkaXN0aW50YSBhIFJFUElTQUxVRCwgdXN0ZWQgYWNlcHRhIHF1ZSBoYSBjdW1wbGlkbyBjb24gZWwgZGVyZWNobyBkZSAKcmV2aXNpw7NuIHkgb3RyYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIGNvbnRyYXRvIG8gYWN1ZXJkby4gCgpSRVBJU0FMVUQgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIHN1KHMpIG5vbWJyZShzKSBjb21vIGF1dG9yKHMpIG8gcHJvcGlldGFyaW8ocykgCmRlbCBkb2N1bWVudG8sIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiwgZXhjZXB0byBzZWfDum4gbG8gcGVybWl0aWRvIHBvciBlc3RhIApsaWNlbmNpYS4gCg== URL https://repisalud.isciii.es/bitstreams/96397d02-2c28-41b9-9ece-ec9acd1c1cd2/download File MD5 04b49f0b6b6bf933a26ff4c0017a37bb 6385301 application/pdf Extremegenomicerosionafter_2016.pdf URL https://repisalud.isciii.es/bitstreams/3ae61f53-4cda-4854-96e5-dcc3e4aae163/download File MD5 fdc7a35255175de859a80bb0064ff163 10508736 application/pdf Extremegenomicerosionafter_supl_2016.pdf URL https://repisalud.isciii.es/bitstreams/9bc0de2d-c42d-400a-9fe9-465fb021c712/download File MD5 4ddce7105966df9ff69d56c4934c3298 321441 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Extremegenomicerosionafter_supl2_2016.xlsx URL https://repisalud.isciii.es/bitstreams/4f52b546-d72d-48f2-a12e-ce39f6aadea3/download File MD5 628aa8542a0f32cbe445b3fc24ae7e3a 98220 text/plain Extremegenomicerosionafter_2016.pdf.txt URL https://repisalud.isciii.es/bitstreams/1b8122d3-a398-418d-9740-078af8602ac0/download File MD5 1ac716e493cc166ebcfa610a50e2d332 325654 text/plain Extremegenomicerosionafter_supl_2016.pdf.txt URL https://repisalud.isciii.es/bitstreams/722e21b2-20a8-4f24-9db2-a8653ece9d05/download File MD5 4d686b0d94027168027e51c008c417a4 100000 text/plain Extremegenomicerosionafter_supl2_2016.xlsx.txt