2026-06-14T06:44:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/85102024-11-29T15:46:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Abascal, Federico author Corvelo, André author Cruz, Fernando author Villanueva-Cañas, José L author Vlasova, Anna author Marcet-Houben, Marina author Martínez-Cruz, Begoña author Cheng, Jade Yu author Prieto, Pablo author Quesada, Víctor author Quilez, Javier author Li, Gang author García, Francisca author Rubio-Camarillo, Miriam author Frias, Leonor author Ribeca, Paolo author Capella-Gutierrez, Salvador Jesus author Rodríguez, José M author Câmara, Francisco author Lowy, Ernesto author Cozzuto, Luca author Erb, Ionas author Tress, Michael L author Rodriguez-Ales, Jose L author Ruiz-Orera, Jorge author Reverter, Ferran author Casas-Marce, Mireia author Soriano, Laura author Arango, Javier R author Derdak, Sophia author Galán, Beatriz author Blanc, Julie author Gut, Marta author Lorente-Galdos, Belen author Andrés-Nieto, Marta author López-Otín, Carlos author Valencia, Alfonso author Gut, Ivo author García, José L author Guigó, Roderic author Murphy, William J author Ruiz-Herrera, Aurora author Marques-Bonet, Tomas author Roma, Guglielmo author Notredame, Cedric author Mailund, Thomas author Albà, M Mar author Gabaldón, Toni author Alioto, Tyler author Godoy, José A author 2016-12-14 BACKGROUND: Genomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction. RESULTS: We generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species. CONCLUSIONS: The genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species. Genome Biol. 2016 ;17(1):251. 10.1186/s13059-016-1090-1 1474-760X 1474-760X Genome biology 27964752 http://hdl.handle.net/20.500.12105/8510 Conservation genomics Genetic diversity Genetic drift Inbreeding Lynx Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx