2026-07-21T10:21:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/85082024-11-30T00:39:28Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Muñoz-Lorente, Miguel A
author
Cano-Martin, Alba C
author
Blasco , MA
funder
Comunidad de Madrid (España)
funder
Worldwide Cancer Research
funder
Botín Foundation
funder
Ministerio de Economía y Competitividad (España)
2019-10-21T10:11:35Z
2019-10-21T10:11:35Z
2019-10-17
Nat Commun. 2019;10(1):4723.
10.1038/s41467-019-12664-x
2041-1723
2041-1723
Nature communications
31624261
http://hdl.handle.net/20.500.12105/8508
Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and less DNA damage with aging. Hyper-long telomere mice are lean and show low cholesterol and LDL levels, as well as improved glucose and insulin tolerance. Hyper-long telomere mice also have less incidence of cancer and an increased longevity. These findings demonstrate that longer telomeres than normal in a given species are not deleterious but instead, show beneficial effects.
eng
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
journal article
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