2026-05-22T00:05:24Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/85082024-11-30T00:39:28Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Muñoz-Lorente, Miguel A author Cano-Martin, Alba C author Blasco , MA author 2019-10-17 Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and less DNA damage with aging. Hyper-long telomere mice are lean and show low cholesterol and LDL levels, as well as improved glucose and insulin tolerance. Hyper-long telomere mice also have less incidence of cancer and an increased longevity. These findings demonstrate that longer telomeres than normal in a given species are not deleterious but instead, show beneficial effects. Nat Commun. 2019;10(1):4723. 10.1038/s41467-019-12664-x 2041-1723 2041-1723 Nature communications 31624261 http://hdl.handle.net/20.500.12105/8508 Mice with hyper-long telomeres show less metabolic aging and longer lifespans