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oai:repisalud.isciii.es:20.500.12105/85032024-09-27T09:08:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Ibáñez, Borja author Aletras, Anthony H author Arai, Andrew E author Arheden, Hakan author Bax, Jeroen J author Berry, Colin author Bucciarelli-Ducci, Chiara author Croisille, Pierre author Dall'Armellina, Erica author Dharmakumar, Rohan author Eitel, Ingo author Fernandez-Jimenez, Rodrigo author Friedrich, Matthias G author Garcia-Dorado, David author Hausenloy, Derek J author Kim, Raymond J author Kozerke, Sebastian author Kramer, Christopher M author Salerno, Michael author Sanchez-Gonzalez, Javier author Sanz, Javier author Fuster, Valentin author 2019-07 After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes. J Am Coll Cardiol. 2019, 74(2): 238-256 10.1016/j.jacc.2019.05.024 1558-3597 07351097 Journal of the American College of Cardiology 31296297 http://hdl.handle.net/20.500.12105/8503 STEMI Area at risk Clinical trial Edema Endpoint Infarct size Magnetic resonance imaging Myocardial infarction Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel