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00925njm 22002777a 4500 dc Magtibay, Karl author Porta-Sanchez, Andreu author Haldar, Shouvik K author Deno, Don Curtis author Massé, Stéphane author Nanthakumar, Kumaraswamy author 2019-09 Omnipolar electrograms (EGMs) make use of biophysical electric fields that accompany activation along the surface of the myocardium. A grid-like electrode array provides bipolar signals in orthogonal directions to deliver catheter-orientation-independent assessments of cardiac electrophysiology. Studies with myocyte monolayers, isolated animal and human hearts, and anesthetized animals validated the tenets of omnipolar EGMs. The combination of information from omnipolar-based activation vectors and voltages may aid in localizing areas of scar, lesion gaps, wavefront disorganization, and fractionation or collision during arrhythmias. The goal of omnipolar EGMs is to better characterize myocardium through reintroducing electrogram direction related fundamentals of cardiac electrophysiology. Card Electrophysiol Clin. 2019, 11(3): 525-536 10.1016/j.ccep.2019.05.003 1877-9190 18779182 Cardiac electrophysiology clinics 31400876 http://hdl.handle.net/20.500.12105/8501 Activation direction Atrial fibrillation Cardiac mapping Conduction velocity Electrogram direction Omnipolar Ventricular tachycardia Wavefront orientation Reinserting Physiology into Cardiac Mapping Using Omnipolar Electrograms