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oai:repisalud.isciii.es:20.500.12105/85002024-09-27T09:57:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Sanchez-Alvarez, Miguel author Strippoli, Raffaele author Donadelli, Massimo author Bazhin, Alexandr V author Cordani, Marco author 2019-09 : The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient-sensing pathway, constitute major targets for selective therapeutic intervention against several types of tumors, due to their extensive rewiring in cancer cells as compared to healthy cells. Here, we discuss the sestrin family of proteins-homeostatic transducers of oxidative stress, and drivers of antioxidant and metabolic adaptation-as emerging targets for pharmacological intervention. These adaptive regulators lie at the intersection of those two priority nodes of interest in antitumor intervention-ROS control and the regulation of cell metabolism and autophagy-therefore, they hold the potential not only for the development of completely novel compounds, but also for leveraging on synergistic strategies with current options for tumor therapy and classification/stadiation to achieve personalized medicine. Cancers (Basel). 2019, 11(10): E1415 10.3390/cancers11101415 2072-6694 Cancers 31546746 http://hdl.handle.net/20.500.12105/8500 ROS Sestrins Autophagy Cancer therapy Nutrient management Stress response Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer