2026-06-14T13:00:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/84972024-11-29T13:59:44Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Fontenete, Silvia
author
Peña-Jiménez, Daniel
author
Perez-Moreno, Mirna Alicia
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía, Industria y Competitividad (España)
2019-10-16T11:48:28Z
2019-10-16T11:48:28Z
2017-06-27
F1000Res. 2017;6:1010
10.12688/f1000research.11357.1
2046-1402
F1000Research
28721207
http://hdl.handle.net/20.500.12105/8497
This short insight covers some of the recent topics relevant to the field of cadherin-catenin adhesion in mediating connections between different cell types, so-called heterotypic or heterocellular connections, in both homeostasis and cancer. These scientific discoveries are increasing our understanding of how multiple cells residing in complex tissues can be instructed by cadherin adhesion receptors to regulate tissue architecture and function and how these cadherin-mediated heterocellular connections spur tumor growth and the acquisition of malignant characteristics in tumor cells. Overall, the findings that have emerged over the past few years are elucidating the complexity of the functional roles of the cadherin-catenin complexes. Future exciting research lies ahead in order to understand the physical basis of these heterotypic interactions and their influence on the behavior of heterogeneous cellular populations as well as their roles in mediating phenotypic and genetic changes as cells evolve through complex environments during morphogenesis and cancer.
eng
Cadherin adhesion
Cadherin catenin
Cancer
Heterocellular adhesion
Heterotypic adhesion
Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/f2ecdf22-d78b-4c51-8dd6-41fb51bbe799/download
File
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HETEROCELLULARCADHERINCONNECTIONS_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/9bd618be-cd73-47a1-a7c3-09d57c24046f/download
File
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HETEROCELLULARCADHERINCONNECTIONS_2017.pdf.txt