2026-06-14T10:38:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/84962024-11-29T16:40:23Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Barrero, Maria Jose
funder
Lilly
2019-10-16T07:49:31Z
2019-10-16T07:49:31Z
2017-05-23
Int J Mol Sci. 2017;18(6). pii: E1108.
10.3390/ijms18061108
1422-0067
1422-0067
International journal of molecular sciences
28545238
http://hdl.handle.net/20.500.12105/8496
Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patients. However, the rate of success is low and a large percentage of treated patients do not experience clinical benefits. Therefore, additional strategies are needed to improve responses and select responsive patients. Emerging data suggest that epigenetic drugs can improve the responses to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and the epigenetic events that take place during immune evasion is critical to providing a rational combined use of immunotherapies and epigenetic drugs. This review focuses in the epigenetic mechanisms involved in the responses to immunotherapy and how current drugs that target epigenetic regulators impact on them.
eng
cancer
epigenetics
immunotherapy
Epigenetic Strategies to Boost Cancer Immunotherapies
journal article
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URL
https://repisalud.isciii.es/bitstreams/1fa79a38-3f3f-4195-99b0-3455012477d6/download
File
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Epigenetic Strategies to Boost_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/5f5bb9f0-9145-44b0-a62b-0e2a7eeab191/download
File
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Epigenetic Strategies to Boost_2017.pdf.txt