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oai:repisalud.isciii.es:20.500.12105/83832024-11-29T20:14:15Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Vojkovics, Dóra author Kellermayer, Zoltán author Kajtár, Béla author Roncador, Giovanna author Vincze, Áron author Balogh, Péter author 2018-02-06 The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components. Although the various transcriptional regulators with fate-determining effects in diversifying the mobile leukocyte subsets have been thoroughly studied and identified, the tissue-specific determinants promoting the regional differentiation of resident mesenchyme are less understood. Of these factors, various members of the NK-class Nkx paralogues have emerged as key regulators for the organogenesis of spleen and mucosal lymphoid tissues, and recent data have also indicated their involvement in various pathological events, including gut inflammation and hematopoietic malignancies. Here, we summarize available data on the roles of Nkx2-3 in lymphoid tissue development and discuss its possible value as a developmental marker and disease-associated pathogenic trait. Biomark Insights. 2018;13:1177271918757480 10.1177/1177271918757480 1177-2719 Biomarker insights 29449776 http://hdl.handle.net/20.500.12105/8383 Nkx2-3 inflammation lymphoid organs lymphoma Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies